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Mescaline
CompoundPsychedelic alkaloid found in peyote and San Pedro cacti with long indigenous ceremonial use.
Example: The Native American Church, founded in 1918 and tracing peyote ceremony back to the 1880s among the Kiowa and Comanche, has the only specific federal legal exemption of its kind in the US — see our Peyote Exemption entry for how that carve-out actually works.