Encyclopedia

Synthetic phenethylamine psychedelic with combined empathogenic and visual effects

Primary receptor psychedelics act on

Potent psychedelic tryptamine known as the 'God Molecule' for its intense mystical effects

Residual positive psychological effects persisting in the days following a psychedelic experience

Traditional Amazonian brew combining DMT-containing plants with MAOIs for a prolonged psychedelic experience

Challenging experience with fear/anxiety

Randomness of brain activity

FDA status granted to expedite development of drugs showing substantial improvement over existing treatments

Sustained attention on one object

Ability to shift perspectives

Experience of breaking through into an apparent alternate dimension at higher DMT doses

Preparatory dietary and behavioral regimen followed before ayahuasca ceremonies

Reduction of self-referential brain activity

Self-referential thinking network

Seeing thoughts as events

Detachment from reality or self

Classic psychedelic naturally found in plants and animals; principal ingredient in ayahuasca

Temporary loss of sense of self

Emotional stability regardless of experience

Reduced sense of self

Reframing emotional memories

Class of substances that increase feelings of empathy, emotional openness, and connectedness (e.g., MDMA)

Microdosing schedule of one dose day followed by two rest days, repeated in 4–8 week cycles

Communication between brain regions

Session with trained facilitator

Practices and strategies aimed at minimizing risks associated with psychedelic use

Persistent visual disturbances

Process of making sense of experience afterward

Post-experience structured processing

Ego expansion after experience

Psychoactive alkaloid from the African iboga plant studied for addiction interruption

Deep absorption meditation states

Dissociative anesthetic with rapid-acting antidepressant properties used in clinical therapy settings

Ritual vomiting during ayahuasca ceremony considered part of physical and psychological cleansing

Technique of soaking ground psilocybin mushrooms in lemon juice to accelerate onset and intensity

Classic psychedelic known for extended duration and profound perceptual and cognitive effects

Unity, transcendence, and deep meaning state

Sub-perceptual dosing

Full psychoactive dose

Non-judgmental present awareness

Awareness of thinking

Therapeutic protocol combining MDMA with psychotherapy, primarily studied for PTSD treatment

Non-classical psychedelic empathogen used in assisted therapy, primarily studied for PTSD treatment

Psychedelic alkaloid found in peyote and San Pedro cacti with long indigenous ceremonial use

Enzyme inhibitor that prevents breakdown of DMT in the gut, enabling oral psychoactive activity in ayahuasca

Collapse of subject-object distinction

Brain's ability to reorganize

Altered states of consciousness

Growth of new neurons

Brain as prediction machine

Adapting behavior aligned with values

Therapeutic protocol combining psilocybin with professional psychotherapy for depression and other conditions

Primary psychedelic compound in magic mushrooms; a prodrug converted to psilocin in the body

Active psychoactive metabolite of psilocybin responsible for the psychedelic effects

Inactive compound that is metabolically converted into an active drug in the body (e.g., psilocybin → psilocin)

Repetitive, often negative thought patterns that psychedelics and meditation may help disrupt

Mindset and environment shaping the experience

Determines importance of stimuli

Avoiding issues via spirituality

Acute psychedelic experience

Sober companion who provides safety and emotional support during a psychedelic experience

Filtering of sensory input

Depression not responsive to treatment

Insight into impermanence and non-self

Observing without identification